Dampened Weighted Least Square for Deconvolution of Bulk mRNA Data

Documentation for package ‘DWLS’ version 0.1

buildSignatureMatrixMAST	Builds a signature matrix from single-cell data by calling MAST.
buildSignatureMatrixUsingSeurat	Builds a signature matrix from single-cell data by calling Seurat.
DEAnalysis	Calculates differentially expressed genes between each cell type and the rest for a given single-cell data set. (Using Seurat's function)
DEAnalysisMAST	Calculates differentially expressed genes between each cell type and the rest for a given single-cell data set. (Using MAST function directly, without using Seurat)
findDampeningConstant	Find a dampening constant for dampened weighted least squares using cross-validation.
solveDampenedWLS	Solve overdetermined system of equations, Sx=B, for x, using dampened weighted least squares.
solveDampenedWLSj	Solve overdetermined system of equations, Sx=B, for x, using dampened weighted least squares given a specific dampening constant
solveOLS	Solve overdetermined system of equations, Sx=B, for x, using constrained ordinary least squares
solveSVR	Solve overdetermined system of equations, Sx=B, for x, using nu-support vector regression with a linear kernel
trimData	Trims bulk data and single-cell signature matrix to contain the same genes